RNA sequencing-based identification of potential targets in acute myeloid leukemia: A case report.

ABSTRACT: Acute myeloid leukemia (AML) refers to heterogenous types of blood cancer which possess a complicated genomic landscape, and multiple novel mutational alterations are frequently being reported. Herein, a case report of a 37-year old AML patient is presented, who was diagnosed following laboratory investigation after admission. The patient had thrombocytopenia, and three consecutive blast counts of 40, 30 and 41%, respectively. A blood sample was collected for whole-genome RNA sequencing to understand the transcriptomic profile at the time of diagnosis and compared with a matched female control. Gene expression was quantified using the RSEM software package. Bioinformatics analysis revealed a significant number of differentially expressed genes in the patient, suggesting a marked change in

SUBMITTER: El-Masry OS 

PROVIDER: S-EPMC7469581 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature