Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study.

ABSTRACT: Although next-generation sequencing-based panel testing is well practiced in the field of cancer medicine for the identification of target molecules in solid tumors, the clinical utility and clinical issues surrounding panel testing in hematological malignancies have yet to be fully evaluated. We conducted a multicenter prospective clinical sequencing study to verify the feasibility of a panel test for hematological tumors, including acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, and diffuse large B-cell lymphoma. Out of 96 eligible patients, 79 patients (82%) showed potentially actionable findings, based on the clinical sequencing assays. We identified that genetic alterations with a strong clinical significance were found at a higher frequency in terms of diagnos

SUBMITTER: Yasuda T 

PROVIDER: S-EPMC7469806 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature