Report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan.

ABSTRACT: Cell line-derived xenograft (CDX) models created by implanting cancer cell lines into immunodeficient mice have contributed largely to the development of cancer drug therapies. However, cell lines often lose their original biological characteristics through many passages and cancer tissues in CDX models have many cancer cells and few cancer stromal cells, therefore CDX models are currently considered not suitable for predicting the results of clinical studies. Conversely, patient-derived xenograft (PDX) models are gaining importance, as human cancer biological characteristics and microenvironments are recreated by implanting tumor tissue into immunodeficient mice. These highly expected, evidently beneficial PDX models have been used in some basic research and are becoming more generalized.

SUBMITTER: Tsumura R 

PROVIDER: S-EPMC7469811 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature