Ontology highlight
ABSTRACT:
SUBMITTER: Oberley MJ
PROVIDER: S-EPMC7469918 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Pediatric blood & cancer 20180524 9
A pediatric patient diagnosed initially with B-lymphoblastic leukemia (B-ALL) relapsed with lineage switch to acute myeloid leukemia (AML) after chimeric antigen receptor T-cell (CAR-T) therapy and hematopoietic stem cell transplant. A TCF3-ZNF384 fusion was identified at diagnosis, persisted through B-ALL relapse, and was also present in the AML relapse cell population. ZNF384-rearrangements define a molecular subtype of B-ALL characterized by a pro-B-cell immunophenotype; furthermore, ZNF384-r ...[more]