How Tasks Change Whole-Brain Functional Organization to Reveal Brain-Phenotype Relationships.

ABSTRACT: Functional connectivity (FC) calculated from task fMRI data better reveals brain-phenotype relationships than rest-based FC, but how tasks have this effect is unknown. In over 700 individuals performing seven tasks, we use psychophysiological interaction (PPI) and predictive modeling analyses to demonstrate that task-induced changes in FC successfully predict phenotype, and these changes are not simply driven by task activation. Activation, however, is useful for prediction only if the in-scanner task is related to the predicted phenotype. To further characterize these predictive FC changes, we develop and apply an inter-subject PPI analysis. We find that moderate, but not high, task-induced consistency of the blood-oxygen-level-dependent (BOLD) signal across individuals is useful for pred

SUBMITTER: Greene AS 

PROVIDER: S-EPMC7469925 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature