Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy.

ABSTRACT: Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce their reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed to further improve the in situ penetration efficiency of chemo-drug-loaded membrane delivery-system formulations and their release profiles at the tumor site. Here, a macrophage-membrane-coated nanoparticle is developed for tumor-targeted chemotherapy delivery with a controlled release profile in response to tumor microenvironment stimuli. Upon fulfilling its mission of tumor homing and RES evasion, the macrophage-membrane coating can be shed via morphological changes driven by extracellular microenvironment stimuli. The nanoparticles disch

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7470025 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature