Synthesis and toxicity assessment of Fe₃O₄ NPs grafted by ∼ NH₂-Schiff base as anticancer drug: modeling and proposed molecular mechanism through docking and molecular dynamic simulation.

ABSTRACT: Superparamagnetic iron oxide nanoparticles have been synthesized using chain length of (3-aminopropyl) triethoxysilane for cancer therapy. First, we have developed a layer by layer functionalized with grafting 2,4-toluene diisocyanate as a bi-functional covalent linker onto a nano-Fe₃O₄ support. Then, they were characterized by Fourier transform infrared, X-ray powder diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and VSM techniques. Finally, all nanoparticles with positive or negative surface charges were tested against K562 (myelogenous leukemia cancer) cell lines to demonstrate their therapeutic efficacy by MTT assay test. We found that the higher toxicity of Fe₃O₄@SiO₂@APTS ∼ Schiff

SUBMITTER: Eshaghi Malekshah R 

PROVIDER: S-EPMC7470030 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature