Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors.

ABSTRACT: ABTRACT In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 position of isatin core exhibited better results compared to unsubstituted derivatives. According to the results of caspase inhibitory activity, compound 20d showed moderate inhibitory activity against caspase-3 and -7 in vitro compared to Ac-DEVD-CHO (IC₅₀ = 0.016 ± 0.002 μM). Among the studied compounds, some active inhibitors with IC_50s in the range of 2.33-116.91 μM were identified. The activity of compound 20d was rationalised by the molecular modelling studies exhibiting the additional va

SUBMITTER: Firoozpour L 

PROVIDER: S-EPMC7470124 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature