Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release.

ABSTRACT: In this work, we prepared a stimuli-responsive system for drug delivery and controlled release by engineering the bovine serum albumin (BSA). The doxorubicin (DOX)-loaded BSA nanoparticles (NPs) were conveniently prepared using desolvation method, followed by crosslinking through Schiff base bonds, leading to pH-sensitive DOX-loaded system (DOX_s@BSA NPs). The resulted DOX_s@BSA NPs showed high drug loading capacity (21.4%), and the particle size was about 130 nm with narrow polydispersity and high negative surface charge (-20.5 mV). The pH-sensitivity of DOX_s@BSA NPs was evidenced by the size changes and charge reversal after incubation at different pH values. The DOX_s@BSA NPs showed high serum stability which indicated the prolonged circulation t

SUBMITTER: Yang Z 

PROVIDER: S-EPMC7470134 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature