Minocycline for symptom reduction during radiation therapy for head and neck cancer: a randomized clinical trial.

ABSTRACT:

Purpose

Local/systemic symptoms during cancer therapy may be exacerbated by dysregulated inflammation and its downstream toxic effects. Minocycline can suppress proinflammatory cytokine release; therefore, we investigated its potential to reduce patient-reported symptom severity during radiotherapy (RT) for head and neck cancer (HNC).

Methods

Eligible patients for this blinded, placebo-controlled trial were adults with T0-3, N-any, and M0 HNC receiving single-modality RT. Participants were randomized 1:1 to either minocycline (200 mg/day) or placebo during RT. The primary endpoint was the area under the curve (AUC) of 5 prespecified symptoms (pain, fatigue, disturbed sleep, poor appetite, difficulty swallowing/chewing) during RT, assessed with the MD Anderson Symptom Invento

SUBMITTER: Gunn GB 

PROVIDER: S-EPMC7470188 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature