The wasting-associated metabolite succinate disrupts myogenesis and impairs skeletal muscle regeneration.

ABSTRACT:

Background

Muscle wasting is a debilitating co-morbidity affecting most advanced cancer patients. Alongside enhanced muscle catabolism, defects in muscle repair/regeneration contribute to cancer-associated wasting. Among the factors implicated in suppression of muscle regeneration are cytokines that interfere with myogenic signal transduction pathways. Less understood is how other cancer/wasting-associated cues, such as metabolites, contribute to muscle dysfunction. This study investigates how the metabolite succinate affects myogenesis and muscle regeneration.

Methods

We leveraged an established ectopic metabolite treatment (cell permeable dimethyl-succinate) strategy to evaluate the ability of intracellular succinate elevation to 1) affect myoblast homeostasis (proliferati

SUBMITTER: Arneson-Wissink PC 

PROVIDER: S-EPMC7470228 | biostudies-literature | 2020 Jul-Dec

REPOSITORIES: biostudies-literature