Dietary antioxidant seleno-L-methionine protects macrophages infected with Burkholderia thailandensis.

ABSTRACT: Burkholderia pseudomallei is a facultative intracellular pathogen and the causative agent of melioidosis, a potentially life-threatening disease endemic in Southeast Asia and Northern Australia. Treatment of melioidosis is a long and costly process and the pathogen is inherently resistant to several classes of antibiotics, therefore there is a need for new treatments that can help combat the pathogen. Previous work has shown that the combination of interferon-gamma, an immune system activator, and the antibiotic ceftazidime synergistically reduced the bacterial burden of RAW 264.7 macrophages that had been infected with either B. pseudomallei or Burkholderia thailandensis. The mechanism of the interaction was found to be partially dependent on interferon-gamma-induced production of reactiv

SUBMITTER: Pomposello MM 

PROVIDER: S-EPMC7470333 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature