Compromised longevity due to Mycobacterium abscessus pulmonary disease in lungs scarred by tuberculosis.

ABSTRACT: Structural lung diseases or scarring related to prior infections such as tuberculosis (TB) are risk factors for the development of invasive nontuberculous mycobacterial (NTM) pulmonary infections, such as Mycobacterium abscessus . M. abscessus is intrinsically resistant to many antibiotics and in vitro susceptibility correlates poorly with clinical response, especially in pulmonary disease. Treatment is often difficult due to the lack of effective antibiotic regimens. We present a case of a 56-year-old male previously treated for TB, with presumed exacerbation, who was diagnosed after much delay with pulmonary M. abscessus disease and subsequently failed initial treatment with an empirical antibiotic regimen. When placed on a synergistic combination regimen that include

SUBMITTER: Singh UB 

PROVIDER: S-EPMC7470354 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature