STK11 (LKB1) mutations in metastatic NSCLC: Prognostic value in the real world.

ABSTRACT:

Background

Mutations in STK11 (STK11m) and frequently co-occurring KRAS mutations (KRASm/STK11m) are associated with poor survival in metastatic NSCLC (mNSCLC) immuno-oncology trials. There are limited data regarding the prognostic significance of these mutations in a real-world setting.

Methods

This retrospective cohort study analyzed de-identified electronic medical records from the Flatiron Clinico-Genomic database to identify patients with mNSCLC who had initiated first-line immunotherapy (IO; alone or in combination) or chemotherapy under routine care between January 1, 2013 and June 30, 2017. The primary objectives were to assess the prevalence of STK11m and KRASm/STK11m and to determine associations of these mutations with overall and progression-free survival (OS, PF

SUBMITTER: Shire NJ 

PROVIDER: S-EPMC7470384 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature