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High HbA1c is associated with decreased 6-month survival and poor outcomes after out-of-hospital cardiac arrest: a retrospective cohort study.

ABSTRACT: BACKGROUND:To evaluate the associations between glycated hemoglobin (HbA1c) at admission and 6-month mortality and outcomes after out-of-hospital cardiac arrest (OHCA) treated by hypothermic targeted temperature management (TTM). METHODS:This single-center retrospective cohort study included adult OHCA survivors who underwent hypothermic TTM from December 2011 to December 2019. High HbA1c at admission was defined as a level higher than 6%. Poor neurological outcomes were defined as cerebral performance category scores of 3-5. The primary outcome was 6-month mortality. The secondary outcome was the 6-month neurological outcome. Descriptive statistics, log-rank tests, and multivariable regression modeling were used for data analysis. RESULTS:Of the 302 patients included in the final analysis, 102 patients (33.8%) had HbA1c levels higher than 6%. The high HbA1c group had significantly worse 6-month survival (12.7% vs. 37.5%, p??6% than in those with HbA1c ?6%. In the multivariable logistic regression analysis, HbA1c >?6% was independently associated with 6-month mortality (OR 5.85, 95% CI 2.26-15.12, p?

SUBMITTER: Lee J 

PROVIDER: S-EPMC7470436 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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High HbA1c is associated with decreased 6-month survival and poor outcomes after out-of-hospital cardiac arrest: a retrospective cohort study.

Lee Junhaeng J   Oh Joo Suk JS   Zhu Jong Ho JH   Hong Sungyoup S   Park Sang Hyun SH   Kim Ji Hoon JH   Kim Hyungsoo H   Seo Mingu M   Kim Kiwook K   Lee Doo Hyo DH   Jung Hyun Ho HH   Park Jungtaek J   Oh Young Min YM   Choi Semin S   Choi Kyoung Ho KH  

Scandinavian journal of trauma, resuscitation and emergency medicine 20200903 1

<h4>Background</h4>To evaluate the associations between glycated hemoglobin (HbA1c) at admission and 6-month mortality and outcomes after out-of-hospital cardiac arrest (OHCA) treated by hypothermic targeted temperature management (TTM).<h4>Methods</h4>This single-center retrospective cohort study included adult OHCA survivors who underwent hypothermic TTM from December 2011 to December 2019. High HbA1c at admission was defined as a level higher than 6%. Poor neurological outcomes were defined a  ...[more]