A seven-gene signature model predicts overall survival in kidney renal clear cell carcinoma.

ABSTRACT:

Background

Kidney renal clear cell carcinoma (KIRC) is a potentially fatal urogenital disease. It is a major cause of renal cell carcinoma and is often associated with late diagnosis and poor treatment outcomes. More evidence is emerging that genetic models can be used to predict the prognosis of KIRC. This study aimed to develop a model for predicting the overall survival of KIRC patients.

Results

We identified 333 differentially expressed genes (DEGs) between KIRC and normal tissues from the Gene Expression Omnibus (GEO) database. We randomly divided 591 cases from The Cancer Genome Atlas (TCGA) into training and internal testing sets. In the training set, we used univariate Cox regression analysis to retrieve the survival-related DEGs and futher used multivariate Cox regr

SUBMITTER: Chen L 

PROVIDER: S-EPMC7470605 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature