Detection of NRG1 Gene Fusions in Solid Tumors.

ABSTRACT:

Purpose

NRG1 gene fusions are rare but potentially actionable oncogenic drivers that are present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking. Here, we assessed the incidence of NRG1 fusions across multiple tumor types and described fusion partners.

Experimental design

Tumor specimens submitted for molecular profiling at a Clinical Laboratory Improvement Amendments (CLIA)-certified genomics laboratory and that underwent fusion testing by anchored multiplex PCR for targeted RNA sequencing were retrospectively identified. The overall and tumor-specific incidence was noted, as was the specific fusion partner.

Results

Out of 21,858 tumor specimens profiled from September 2015 to December 2018, 41 cases (0.2%)

SUBMITTER: Jonna S 

PROVIDER: S-EPMC7470623 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature