A protein interaction map identifies existing drugs targeting SARS-CoV-2.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus (SARS-CoV-2), an emerging Betacoronavirus, is the causative agent of COVID-19. Angiotensin converting enzyme 2 (ACE2), being the main cell receptor of SARS-CoV-2, plays a role in the entry of the virus into the cell. Currently, there are neither specific antiviral drugs for the treatment or preventive drugs such as vaccines.

Methods

We proposed a bioinformatics analysis to test in silico existing drugs as a fast way to identify an efficient therapy. We performed a differential expression analysis in order to identify differentially expressed genes in COVID-19 patients correlated with ACE-2 and we explored their direct relations with a network approach integrating also drug-gene interactions. The drugs with a central ro

SUBMITTER: Cava C 

PROVIDER: S-EPMC7470683 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature