Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients.

ABSTRACT:

Purpose

The aim of this study was to investigate potential markers of coagulopathy and the effects of thromboprophylaxis with low-molecular-weight heparin (LMWH) on thromboelastography (TEG) and anti-factor Xa in critically ill COVID-19 patients.

Material and methods

We conducted a prospective study in 31 consecutive adult intensive care unit (ICU) patients. TEG with and without heparinase and anti-factor Xa analysis were performed. Standard thromboprophylaxis was given with dalteparin (75-100 IU/kg subcutaneously).

Results

Five patients (16%) had symptomatic thromboembolic events. All patients had a maximum amplitude (MA) > 65 mm and 13 (42%) had MA > 72 mm at some point during ICU stay. Anti-factor Xa activity were below the target range in 23% of the patients and a

SUBMITTER: Stattin K 

PROVIDER: S-EPMC7470731 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature