Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach.

ABSTRACT: Chinese herbal medicine (CHM) addresses complex diseases through polypharmacological interactions. However, systematic studies of herbal medicine pharmacology remain challenging due to the complexity of CHM ingredients and their interactions with various targets. In this study, we aim to address this challenge with computational approaches. We investigated the herb-target-disease associations of 197 commonly prescribed CHMs using the similarity ensemble approach and DisGeNET database. We demonstrated that this method can be applied to associate herbs with their putative targets. In the case study of three well-known herbs, Radix Glycyrrhizae, Flos Lonicerae, and Rhizoma Coptidis, approximately 70% of the predicted targets were supported by scientific literature. By linking 406 targets to 2

SUBMITTER: Gu S 

PROVIDER: S-EPMC7470807 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature