β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK_1/2-NF-κB signal pathway in murine hearts.

ABSTRACT: Evidence to date suggests that β-arrestins act beyond their role as adapter proteins. Arginine vasopressin (AVP) may be a factor in inflammation and fibrosis in the pathogenesis of heart failure. In the present study we investigated the effect of AVP on inflammatory cytokine IL-6 production in murine hearts and the impact of β-arrestin 2-dependent signaling on AVP-induced IL-6 production. We found that administration of AVP (0.5 U/kg, iv) markedly increased the levels of IL-6 mRNA in rat hearts with the maximum level occurred at 6 h. In β-arrestin 2 KO mouse hearts, deletion of β-arrestin 2 decreased AVP-induced IL-6 mRNA expression. We then performed in vitro experiments in adult rat cardiac fibroblasts (ARCFs). We found that AVP (10^-9-10^-6 M) dose-dependently increa

SUBMITTER: Sun SZ 

PROVIDER: S-EPMC7470839 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature