Geometric models for robust encoding of dynamical information into embryonic patterns.

ABSTRACT: During development, cells gradually assume specialized fates via changes of transcriptional dynamics, sometimes even within the same developmental stage. For anterior-posterior (AP) patterning in metazoans, it has been suggested that the gradual transition from a dynamic genetic regime to a static one is encoded by different transcriptional modules. In that case, the static regime has an essential role in pattern formation in addition to its maintenance function. In this work, we introduce a geometric approach to study such transition. We exhibit two types of genetic regime transitions arising through local or global bifurcations, respectively. We find that the global bifurcation type is more generic, more robust, and better preserves dynamical information. This could parsimoniously explai

SUBMITTER: Jutras-Dube L 

PROVIDER: S-EPMC7470844 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature