Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding.

ABSTRACT: α-Synuclein (aSyn) participates in synaptic vesicle trafficking and synaptic transmission but its misfolding is also strongly implicated in Parkinson's disease (PD) and other neurodegenerative synucleinopathies in which misfolded aSyn accumulates in different regions of the central and peripheral nervous systems. Although increased aSyn expression levels or altered aggregation propensities likely underlie familial PD with SNCA amplification or mutations, the majority of synucleinopathies arise sporadically, indicating that disease can develop under normal levels of wild-type (wt) aSyn. We report here the development and characterization of a mouse line expressing an aSyn-green fluorescence protein (GFP) fusion protein under the control of native Snca regulatory elements. Regional and subce

SUBMITTER: Caputo A 

PROVIDER: S-EPMC7470929 | biostudies-literature | 2020 Jul/Aug

REPOSITORIES: biostudies-literature