Frequency and hydrogen bonding of nucleobase homopairs in small molecule crystals.

ABSTRACT: We used the high resolution and accuracy of the Cambridge Structural Database (CSD) to provide detailed information regarding base pairing interactions of selected nucleobases. We searched for base pairs in which nucleobases interact with each other through two or more hydrogen bonds and form more or less planar structures. The investigated compounds were either free forms or derivatives of adenine, guanine, hypoxanthine, thymine, uracil and cytosine. We divided our findings into categories including types of pairs, protonation patterns and whether they are formed by free bases or substituted ones. We found base pair types that are exclusive to small molecule crystal structures, some that can be found only in RNA containing crystal structures and many that are native to both environments.

SUBMITTER: Cabaj MK 

PROVIDER: S-EPMC7470937 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature