Grade I, II and III Follicular Lymphomas Express Ig V_H Genes with Different Patterns of Somatic Mutation.

ABSTRACT: Follicular lymphoma (FL) is an indolent, B-cell, non-Hodgkin's lymphoma with varying cytological appearance and clinical behavior. The genetic hallmark of FL is the t(14;18) translocation, and as a germinal center derived entity it is also characterized by somatic hypermutation of the immunoglobulin heavy chain (IgH) gene. In an attempt to correlate this molecular signature with the cytological grading of FL, we have analyzed the IgH variable (IgV_H), regions in all cytological grades of FL. Four FL cases showing t(14;18) translocation were classified into grade I-III categories according to the current WHO guidelines. The IgV_H gene segments were PCR-amplified, sequenced, and compared to their respective germline IgV_H sequences. The neoplastic cells of grade

SUBMITTER: Csernus B 

PROVIDER: S-EPMC7471144 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature