Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration.

ABSTRACT: Determining the selective potential of antibiotics at environmental concentrations is critical for designing effective strategies to limit selection for antibiotic resistance. This study determined the minimal selective concentrations (MSCs) for macrolide and fluoroquinolone antibiotics included on the European Commission's Water Framework Directive's priority hazardous substances Watch List. The macrolides demonstrated positive selection for ermF at concentrations 1-2 orders of magnitude greater (>500 and <750 µg/L) than measured environmental concentrations (MECs). Ciprofloxacin illustrated positive selection for intI1 at concentrations similar to current MECs (>7.8 and <15.6 µg/L). This highlights the need for compound specific assessment of selective potential. In addition, a sub-MSC s

SUBMITTER: Stanton IC 

PROVIDER: S-EPMC7471295 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature