Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes.

ABSTRACT: Patients with advanced-stage colon cancer often exhibit resistance against treatment and distant metastasis, both key contributors to poor prognosis. Emerging evidence indicates that cancer stem cells (CSCs), characterized by the enhanced ability to self-renew, resist therapeutics, and promote metastasis, represents a clinical challenge to target. Alternative therapeutic approaches are urgently required. Here, we explored the feasibility of disrupting the intracellular communications between CSCs and the tumor microenvironment by way of exosomes. First, we demonstrated that exosomes secreted by colon tumorspheres (Exo^sp) promoted 5-FU resistance, migration, and tumorsphere formation. Exo^sp also increased the generation of cancer-associated fibroblasts and M2 polarized

SUBMITTER: Huang YJ 

PROVIDER: S-EPMC7471366 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature