Subtype switching in breast cancer brain metastases: a multicenter analysis.

ABSTRACT:

Background

Breast cancer (BC) brain metastases (BM) can have discordant hormonal or human epidermal growth factor receptor 2 (HER2) expression compared with corresponding primary tumors. This study aimed to describe incidence, predictors, and survival outcomes of discordant receptors and associated subtype switching in BM.

Methods

BCBM patients seen at 4 tertiary institutions who had undergone BM resection or biopsy were included. Surgical pathology reports were retrospectively assessed to determine discordance between the primary tumor and the BCBM. In discordant cases, expression in extracranial metastases was also assessed.

Results

In BM from 219 patients, prevalence of any discordance was 36.3%; receptor-specific discordance was 16.7% for estrogen, 25.2% for proge

SUBMITTER: Hulsbergen AFC 

PROVIDER: S-EPMC7471502 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature