Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.

ABSTRACT: GABAergic interneurons (GINs) are a heterogeneous population of inhibitory neurons that collectively contribute to the maintenance of normal neuronal excitability and network activity. Identification of the genetic regulatory elements and transcription factors that contribute toward GIN function may provide new insight into the pathways underlying proper GIN activity while also indicating potential therapeutic targets for GIN-associated disorders, such as schizophrenia and epilepsy. In this study, we examined the temporal changes in gene expression and chromatin accessibility during GIN development by performing transcriptomic and epigenomic analyses on human induced pluripotent stem cell-derived neurons at 22, 50 and 78 days (D) post-differentiation. We observed 13 221 differentially acce

SUBMITTER: Inglis GAS 

PROVIDER: S-EPMC7471504 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature