Genetic profiling of somatic alterations by Oncomine Focus Assay in Korean patients with advanced gastric cancer.

ABSTRACT: Gastric cancer is one of the leading causes of cancer-associated death; however, analysis of its molecular and clinical characteristics has been complicated by its histological and etiological heterogeneity. The present study aimed to estimate somatic mutation profiling in gastric cancer. To do so, targeted next-generation sequencing (NGS) was performed with the Oncomine Focus Assay to compare the clinicopathological characteristics with the mutation profiles in 50 patients with advanced gastric cancer (AGC). Among the 35 hotspot genes and 19 genes for copy number variations (CNVs), 18 single nucleotide variants (SNVs) or small insertions and deletions (14 missense and four frameshift mutations), and 10 amplifications were identified. To examine the association between mutation profiles an

SUBMITTER: Park J 

PROVIDER: S-EPMC7471730 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature