Sterically stabilized liposomes targeting P21 (RAC1) activated kinase-1 and secreted phospholipase A₂ suppress prostate cancer growth and metastasis.

ABSTRACT: Metastatic prostate cancer (PCa) has a very high mortality rate in men, in Western countries and lacks reliable treatment. The advanced-stage PCa cells overexpress P21 (RAC1) activated kinase-1 (PAK1) and secreted phospholipase A₂ (sPLA₂) suggesting the potential utility of pharmacologically targeting these molecules to treat metastatic PCa. The small molecule, inhibitor targeting PAK1 activation-3 (IPA3) is a highly specific allosteric inhibitor of PAK1; however, it is metabolically unstable once in the plasma thus, limiting its utility as a chemotherapeutic agent. In the present study, the efficacy and specificity of IPA3 were combined with the stability and the sPLA₂-targeted delivery method of two sterically stabilized liposomes [sterically stabilized l

SUBMITTER: Verma A 

PROVIDER: S-EPMC7471734 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature