The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection.

ABSTRACT: The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus 2 presents with a spectrum of clinical manifestations from asymptomatic or mild, self-limited constitutional symptoms to a hyperinflammatory state ("cytokine storm") followed by acute respiratory distress syndrome and death. The objective of this study was to provide an evidence-based review of the associated pathways and potential treatment of the hyperinflammatory state associated with severe acute respiratory syndrome coronavirus 2 infection. Dysregulated immune responses have been reported to occur in a smaller subset of those infected with severe acute respiratory syndrome coronavirus 2, leading to clinical deterioration 7 to 10 days after initial presentation. A hyperinflammatory state refer

SUBMITTER: Copaescu A 

PROVIDER: S-EPMC7471766 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature