Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia.

ABSTRACT: Endometrial hyperplasia (EH) is a condition where uterine endometrial glands show excessive proliferation of epithelial cells that may subsequently progress into endometrial cancer (EC). Modern lifestyle disorders such as obesity, hormonal changes and hyperinsulinemia are known risk factors for EH. A mouse strain that mimics most of these risk factors would be an ideal model to study the stage-wise progression of EH disease and develop suitable treatment strategies. Wdr13, an X-linked gene, is evolutionarily conserved and expressed in several tissues including uteri. In the present study, Wdr13 knockout female mice developed benign proliferative epithelium that progressed into EH at around one year of age accompanied by an increase in body weight and elevated estradiol levels. Molecular ch

SUBMITTER: Singh S 

PROVIDER: S-EPMC7471898 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature