Antinociceptive and anxiolytic-like effects of a neo-clerodane diterpene from Salvia semiatrata aerial parts.

ABSTRACT:

Context

Salvia semiatrata Zucc. (Lamiaceae) is a species used as a tranquilizer and to relieve pain in folk medicine in Santiago Huauclilla, Oaxaca, Mexico.

Objective

To evaluate the antinociceptive and anxiolytic-like effects of S. semiatrata extracts and identify a bioactive metabolite.

Materials and methods

The extracts were obtained by maceration of S. semiatrata aerial parts using solvents in increasing polarity (hexane, ethyl acetate and methanol). A neo-clerodane diterpene was extracted from the ethyl acetate fraction using open column chromatography. Identification of this metabolite was performed by crystallography, ¹H NMR, ¹³C NMR, ATR-IR, ECD, MS and elemental analysis. The antinociceptive activity was explo

SUBMITTER: Ortiz-Mendoza N 

PROVIDER: S-EPMC7471977 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature