In Vivo Tumor Vascular Imaging with Light Emitting Diode-Based Photoacoustic Imaging System.

ABSTRACT: Photoacoustic (PA) imaging has shown tremendous promise for imaging tumor vasculature and its function at deeper penetration depths without the use of exogenous contrast agents. Traditional PA imaging systems employ expensive and bulky class IV lasers with low pulse repetition rate, due to which its availability for preclinical cancer research is hampered. In this study, we evaluated the capability of a Light-Emitting Diode (LED)-based PA and ultrasound (US) imaging system for monitoring heterogeneous microvasculature in tumors (up to 10 mm in depth) and quantitatively compared the PA images with gold standard histology images. We used a combination of a 7 MHz linear array US transducer and 850 nm excitation wavelength LED arrays to image blood vessels in a subcutaneous tumor model. After

SUBMITTER: Xavierselvan M 

PROVIDER: S-EPMC7472236 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature