Evaluation of Antifungal Activity of Naja pallida and Naja mossambica Venoms against Three Candida Species.

ABSTRACT: In contrast to comprehensively investigated antibacterial activity of snake venoms, namely crude venoms and their selected components, little is known about antifungal properties of elapid snake venoms. In the present study, the proteome of two venoms of red spitting cobra Naja pallida (NPV) and Mozambique spitting cobra Naja mossambica (NMV) was characterized using LC-MS/MS approach, and the antifungal activity of crude venoms against three Candida species was established. A complex response to venom treatment was revealed. NPV and NMV, when used at relatively high concentrations, decreased cell viability of C. albicans and C. tropicalis, affected cell cycle of C. albicans, inhibited C. tropicalis-based biofilm formation and promoted oxidat

SUBMITTER: Kuna E 

PROVIDER: S-EPMC7472363 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature