Curcumin, a Multi-Ion Channel Blocker That Preferentially Blocks Late Na⁺ Current and Prevents I/R-Induced Arrhythmias.

ABSTRACT: Increasing evidence shows that Curcumin (Cur) has a protective effect against cardiovascular diseases. However, the role of Cur in the electrophysiology of cardiomyocytes is currently not entirely understood. Therefore, the present study was conducted to investigate the effects of Cur on the action potential and transmembrane ion currents in rabbit ventricular myocytes to explore its antiarrhythmic property. The whole-cell patch clamp was used to record the action potential and ion currents, while the multichannel acquisition and analysis system was used to synchronously record the electrocardiogram and monophasic action potential. The results showed that 30 μmol/L Cur shortened the 50 and 90% repolarization of action potential by 17 and 7%, respectively. In addition, Cur concentration dep

SUBMITTER: Song L 

PROVIDER: S-EPMC7472421 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature