Zolpidem reduces pain intensity postoperatively: a systematic review and meta-analysis of the effect of hypnotic medicines on post-operative pain intensity.

ABSTRACT:

Background

This systematic review aimed to investigate whether the administration of hypnotic medicines, z-drugs, melatonin or benzodiazepines, reduced pain intensity postoperatively.

Methods

Medline, Embase, Cinahl, Psych info, Central and PubMed databases were searched, from inception to February 2020 to identify relevant trials. The search was extended, post hoc, to include meta-Register of Controlled Trials, the Web of Science and the conference booklets for the 14th, 15th, and 16th International Association for the Study of Pain conferences. Two independent reviewers screened titles and abstracts and cross-checked the extracted data.

Results

The search retrieved 5546 articles. After full-text screening, 15 trials were included, which had randomised 1252 participa

SUBMITTER: O'Hagan ET 

PROVIDER: S-EPMC7472584 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature