Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants.

ABSTRACT:

Background

Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer's disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory, and behavior. Transactive response DNA-binding protein 43 (TDP-43) pathology is found in most FTD and ALS cases. It plays a role in transcription, translation and serves as a shuttle between the nucleus and cytoplasm. Prior to its aggregation, TDP-43 exists as polyubiquitinated, hyperphosphorylated C-terminal fragments that correlate well with FTD disease progression. Because of the importance of TDP-43 in these diseases, reagents that can selectively recognize specific toxic TDP variants associated with onset and progression of FTD can be effective diagnostic and

SUBMITTER: Venkataraman L 

PROVIDER: S-EPMC7472585 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature