Selective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles.

ABSTRACT: Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.

SUBMITTER: Zangiabadi M 

PROVIDER: S-EPMC7472588 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature