COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics.

ABSTRACT:

Purpose

The coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8 million lives across the world and raised a major global health concern. We survey the history and mechanism of coronaviruses, and the structural characteristics of the spike protein and its key residues responsible for human transmissions.

Methods

We have carried out a systematic review to summarize the origin, transmission and etiology of COVID-19. The structural analysis of the spike protein and its disordered residues explains the mechanism of the viral transmission. A meta-data analysis of the therapeutic compounds targeting the SARS-CoV-2 is also included.

Results

Coronaviruses can cross the species barrier and infect humans with unexpected consequences for public health. The t

SUBMITTER: Yesudhas D 

PROVIDER: S-EPMC7472674 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature