Genetic Variants in miRNAs Are Associated With Risk of Non-syndromic Tooth Agenesis.

ABSTRACT: Non-syndromic tooth agenesis (NSTA) is one of the most common dental abnormalities. MiRNAs participated in the craniofacial and tooth development. Therefore, single nucleotide polymorphisms (SNPs) in miRNA genes may contribute to the susceptibility of non-syndromic tooth agenesis. Here, a total of 625 non-syndromic tooth agenesis cases and 1,144 healthy controls were recruited, and four miRNA SNPs (miR-146a/rs2910164, miR-196a2/rs11614913, pre-miR-605/rs2043556, pre-miR-618/rs2682818) were genotyped by the TaqMan platform. Rs2043556 showed nominal associations with risk of non-syndromic tooth agenesis (P _Add = 0.021) in the overall analysis, as well as upper lateral incisor agenesis (P _Add = 0.047) and lower incisor agenesis (

SUBMITTER: Gu M 

PROVIDER: S-EPMC7472694 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature