Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia.

ABSTRACT: The pursuit of relating the location of neural damage to the pattern of acquired language and general cognitive deficits post-stroke stems back to the 19th century behavioural neurology. While spatial specificity has improved dramatically over time, from the large areas of damage specified by post-mortem investigation to the millimetre precision of modern MRI, there is an underlying issue that is rarely addressed, which relates to the fact that damage to a given area of the brain is not random but constrained by the brain's vasculature. Accordingly, the aim of this study was to uncover the statistical structure underlying the lesion profile in chronic aphasia post-stroke. By applying varimax-rotated principal component analysis to the lesions of 70 patients with chronic post-stroke aphasia

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7472896 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature