Working memory training increases neural efficiency in Parkinson's disease: a randomized controlled trial.

ABSTRACT: Impairment of working memory and executive functions is already frequently observed in early stages of Parkinson's disease. Improvements in working memory performance in this cohort could potentially be achieved via working memory training. However, the specific neural mechanisms underlying different working memory processes such as maintenance as opposed to manipulation are largely under-investigated in Parkinson's disease. Moreover, the plasticity of these correlates as a function of working memory training is currently unknown in this population. Thus, the working memory subprocesses of maintenance and manipulation were assessed in 41 cognitively healthy patients with Parkinson's disease using a newly developed working memory paradigm and functional MRI. Nineteen patients were randomize

SUBMITTER: Giehl K 

PROVIDER: S-EPMC7472906 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature