An immunoinformatics study on the spike protein of SARS-CoV-2 revealing potential epitopes as vaccine candidates.

ABSTRACT:

Background

The pandemic situation of SARS-CoV-2 infection has sparked global concern due to the disease COVID-19 caused by it. Since the first cluster of confirmed cases in China in December 2019, the infection has been reported across the continents and inflicted upon a substantial number of populations.

Method

This study is focused on immunoinformatics analyses of the SARS-CoV-2 spike glycoprotein (S protein) which is key for the viral attachment to human host cells. Computational analyses were carried out for the prediction of B-cell and T-cell (MHC class I and II) epitopes of S protein and the analyses were extended further for the prediction of their immunogenic properties. The interaction and binding affinity of T-cell epitopes with HLA-B7 were also investigated by mol

SUBMITTER: Ashik AI 

PROVIDER: S-EPMC7472982 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature