Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the fifth most common cancer. Since changes in liver metabolism contribute to liver disease development, it is necessary to build a metabolism-related prognostic model for HCC.

Methods

We constructed a metabolism-related-gene (MRG) signature comprising nine genes, which segregated HCC patients into high- and low-risk groups.

Results

The survival rate (overall survival: OS; relapse-free survival; and progression-free survival) of patients in the low-risk group of The Cancer Genome Atlas (TCGA) cohort was significantly higher than that of patients in the high-risk group. The OS prognostic signature was validated in the International Cancer Genome Consortium independent cohort. The corresponding receiver operating characterist

SUBMITTER: Tang C 

PROVIDER: S-EPMC7473097 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature