Serum progranulin levels are associated with frailty in middle-aged individuals.

ABSTRACT:

Background and objective

A recent study identified progranulin as a candidate biomarker for frailty, based on gene expression databases. In the present study, we investigated associations between serum progranulin levels and frailty in a population-based sample of late middle-age and older adults.

Methods

We utilized a cohort study that included 358 African Americans (baseline ages 49-65). Frailty was assessed by three established methods: the interview-based FRAIL scale, the Cardiovascular Health Study (CHS) frailty scale that includes performance-based measurements, and the Frailty Index (FI) that is based on cumulative deficits. Serum levels of the following proteins and metabolites were measured: progranulin, cystatin C, fructosamine, soluble cytokine receptors (interleu

SUBMITTER: Nguyen AD 

PROVIDER: S-EPMC7473561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature