Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment.

ABSTRACT: During antiretroviral therapy (ART) that suppresses HIV replication to below the limit-of-quantification, virions produced during ART can be detected at low frequencies in the plasma, termed residual viremia (RV). We hypothesized that a reservoir of HIV-infected cells actively produce and release virions during ART that are potentially infectious, and that following ART-interruption, these virions can complete full-cycles of replication and contribute to rebound viremia. Therefore, we studied the dynamics of RV sequence variants in 3 participants who initiated ART after ~3 years of infection and were ART-suppressed for >6 years prior to self-initiated ART-interruptions. Longitudinal RV C2V5env sequences were compared to sequences from pre-ART plasma, supernatants of quantitative viral outg

SUBMITTER: Aamer HA 

PROVIDER: S-EPMC7473585 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature