Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders.

ABSTRACT: The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE on LOAD risk and endophenotypes have yet to be explained. In this Review, we revisit the different aspects of APOE involvement in neurodegeneration and neurological diseases, with particular attention to sex differences in the contribution of APOE to LOAD susceptibility. We discuss the role of APOE in a broader range of age-related neurodegenerative diseases, and summarize the biological factors linking APOE to sex hormones, drawing on supportive findings from rodent models to identify major mechanistic themes underlying the exacerbation of LOAD-associa

SUBMITTER: Gamache J 

PROVIDER: S-EPMC7473656 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature