Interconnectivity between molecular subtypes and tumor stage in colorectal cancer.

ABSTRACT:

Background

There are profound individual differences in clinical outcomes between colorectal cancers (CRCs) presenting with identical stage of disease. Molecular stratification, in conjunction with the traditional TNM staging, is a promising way to predict patient outcomes. We investigated the interconnectivity between tumor stage and tumor biology reflected by the Consensus Molecular Subtypes (CMSs) in CRC, and explored the possible value of these insights in patients with stage II colon cancer.

Methods

We performed a retrospective analysis using clinical records and gene expression profiling in a meta-cohort of 1040 CRC patients. The interconnectivity of tumor biology and disease stage was assessed by investigating the association between CMSs and TNM classification. In or

SUBMITTER: Coebergh van den Braak RRJ 

PROVIDER: S-EPMC7473811 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature